The semen A man who brought a rare carcinogenic mutation used to arrest at least 67 children across Europe, with 10 of them being diagnosed with cancer.
The case of a man with rare carcinogenic mutation, which concerns dozens of children born between 2008 and 2015raises new concerns about the complexity of identifying so many families when a serious medical problem is found, in this case of cancer, as the Guardian.
This is a case that highlighted concerns about the lack of internationally agreed limits for the use of donors spermsince experts in Europe and not only have warned in the past for their social and psychological dangers From the use of semen by individual donors to create a large number of children in different countries.
‘We must have a European limit For the number of births or families for a single donor, “said Dr. Edwige KasperBiologist at Rouen University Hospital in France, who presented the case at the Annual Conference of the European Society of Human Genetics in Milan.
The case came to light when two families contacted independently with fertility clinics after their children have had cancer which seemed to be associated with a rare genetic mutation. The European Sperm Bank, which had supplied the sperm, confirmed that the mutation in a gene called TP53 was present in the donor sperm.
The rare mutation was not known Cancer linked at the time of donation in 2008, could not be detected with the usual control techniques and the donor is in good health.
However, the analysis by Kasper’s laboratory concluded that The mutation was likely to cause Li-Fraumeni syndromeone of the most serious hereditary predispositions for cancer.
At the same time, some sections of genetics and pediatrics across Europe were investigating their own cases, resulting in them examined 67 children from 46 families in 8 European countries. The mutation was found in 23 children, 10 of which have been diagnosed with cancer, including cases of leukemia and non -Hodgkin lymphoma.
The children with the risk gene is recommended to are being watched With regular magnetic resonance imaging of the whole body, magnetic resonance imaging of the brain and, as adults, breast and ultrasound examinations of the abdomen.
The European Bank of Sperm, which applies a global limit of 75 families for each sperm donorhe said that more than 67 children have been arrested using donor sperm, but that her policy is not to confirm the exact number of children for a particular donor. He said that all relevant clinics had been notified.