Strong seems to be the relationship between metabolic syndromeY and skin diseases. Studies show that some of them may be manifestations of systemic disorders. These include the psoriasisacne, atopic dermatitis, androgenic alopecia, and many others.
“Skin problems are often in people with metabolic syndrome. Also, quite often the appearance of a skin disease draws attention to the existence of the syndrome. The exact relationship is being investigated. It is believed that any disorder that leads to loss of metabolic control can cause skin manifestations. The accumulation of fat that characterizes metabolic syndrome, along with the gradual increase in insulin resistance, causes hormonal changes, which result in the appearance and deterioration of skin -affected skin disease, such as hormones, such as acne and the androgenic alopecia. In addition, there is evidence that inflammatory agents and oxidative stress play an important role in many autoimmune and inflammatory skin diseases. These factors are at high levels in patients with syndrome, ”explains Dermatologist – Venereologist Dr. Christos Stamou.
Metabolic syndrome includes a combination of factors predisposed to cardiovascular disease, diabetes mellitus Type 2 and increased mortality for every cause. Patients with it have at least three of the following medical problems: hypertension, increased waist circumference, elevated triglycerides, increased fasting glucose, low levels of high density lipoprotein (HDL). Saugural life and poor nutrition is one of the main dangers for its development.
The most well -known skin diseases associated with epidemiological studies to metabolic syndrome are as follows:
Acne
Acne is an inflammatory disorder that affects many adolescents and young adults. The mechanisms involved in its development are affected by the increase in androgens, while in women, dermatopathy has been linked to a worsening of the lipid profile regardless of hyperandrogenism.
In a study comparing the metabolic condition of 100 men with acne and 100 without, it turned out that the prevalence of metabolic syndrome tends to be higher in acne patients (17%) compared to those who constituted the control group (9%). Another study also found that insulin levels are significantly higher in acne patients.
The prevailing theory is that the visceral obesity triggers a torrent of problemsincluding insulin resistance and chronic inflammation, which are key factors for both the onset and for the evolution of acne.
Acne rose
Rhodes acne is a complex, chronic facial skin disorder with a series of overlapping characteristics such as persistent erythema, tidlangectasia, pawns, blisters and sometimes ocular manifestations. It is believed to be caused by a disturbed and overactive immune system, which can cause inflammation and vasodilation.
One study showed that patients with rosacea had a higher incidence of dyslipidemia and cardiovascular disease. After that, another study found that metabolic syndrome and insulin resistance were higher in the rosacea group compared to the control group in which healthy individuals participated. Scientists have assumed that insulin resistance and rose acne have similar pathophysiological factors and recommended that insulin resistance to those suffering from rosacea.
Psoriasis
Psoriasis is one of the most common chronic inflammatory skin diseases, with prevalence ranging from 0.51 to 11.43% in adults and from 0 to 1.37% in children, and is increasingly recognized as systemic inflammatory disorder.
The association between psoriasis and syndrome has been investigated in numerous studies.
Two recent reviews have shown that the patients with psoriasis have an increased risk for metabolic syndrome. In a meta-analysis of 35 studies with 1,450,188 participants, of which 46,714 were patients with psoriasis, it was found that patients had a higher incidence of the syndrome than the general population.
Obesity is an independent factor for psoriasis and the risk increases in women with a higher body mass index. Evidence also shows that weight loss helps to reduce the severity of psoriasis and the effectiveness of biological treatment.
Androgenic alopecia
Androgenic alopecia is a common type progressive non -ulitic hair loss affecting both sexes. Its incidence varies depending on the breed and age. About 30% of Caucasian men will have this type of hair loss at the age of 30, 50% at the age of 50 and 80% at the age of 70 years. Its prevalence in Caucasian Women is about 19%.
Numerous studies support the strong correlation between androgenic alopecia and metabolic syndrome. One study found a higher prevalence of syndrome in patients with androgenic alopecia (53%) than the participants in the control group (17%). Researchers in a study conducted in Taiwan said that high density lipoprotein cholesterol was the most decisive factor in the occurrence of hair loss, while another that the waist circumference (> 102 cm) was the most important risk factor for patients with androgenic patients.
Atopic dermatitis
Atopic dermatitis is one chronic inflammatory skin diseasewhich may coexist with other atopic disorders, including food allergieshis asthma, of allergic fever and her allergic rhinitis. The incidence of it worldwide is about 15–20% in children and 1–3% in adults.
Determination of the relationship between dermatitis and syndrome has not been fully clarified. A study at 5.007 adults found that metabolic syndrome, central obesity and hypertriglyceridemia are positively related to atopic dermatitis in women. In addition, a review, which included 14 studies, said that central obesity is associated with increased prevalence and severity of atopic dermatitis. This phenomenon was confirmed by other studies and reviews.
“The list of dermatopathy associated with metabolic syndrome includes other less rarer, such as interpretal sweatadeenitis, brunetting acanthosis, hypertrosis, smooth lichen. Immediately or indirectly have been linked to metabolic syndrome and nodular thicks of the dorsal surface of the dorsal surface of the medium joints, vitiligo and limited wound healing. There is evidence that metabolic syndrome also affects the aging of the skin.
Patients with these diseases should be examined for metabolic syndrome, as this can help on the early diagnosis of a systemic disease with numerous complications, on the other hand, to better treat dermatopathy, as they respond better to treatment if the underlying metabolic problems are treated.